Diabetic Nephrophaty in Children

Long-term microvascular and neurologic complications cause major morbidity and mortality in patients with insulin-dependent diabetes mellitus (IDDM) 2. The incidence of overt nephropathy rapidly grows 10-15 years after the onset of type 1 diabetes mellitus; the incidence of nephropathy declines after that period and the occurence of nephropathy after 35 years of duration of type 1 diabetes is uncommon. Diabetic nephropathy rarely develops before 10 years' duration of IDDM. The peak incidence (3% per year) is usually found in persons who have had diabetes for 10-20 years. The increased mortality risk in long-term T1DM may be due to nephropathy, which may account for about 50% of deaths. Epidemiologic data derived from one of the studies – EDC – showed that in group of patients aged <18 and with the duration of diabetes over 5 years the prevalence of microalbuminia reached as much as 14%. Long-term diabetes further increased the prevalence of albuminiria, thus 80% of male and 50% of female patients having diabetes up to 30 years of duration had proteinuria in microor macroalbuminuric range. (3-4)